Work

Phrenic motor output following acute hyperbaric oxygen exposure

Year: 2025

Type: article

Abstract: We studied adult male rats to determine if phrenic motor output is altered following acute hyperbaric oxygen (HBO) pretreatment. Rats were treated with 1-h of 100 % O 2 at 2 atmospheres (HBO, n = 12) or 21 % O 2 at 1 atmosphere (normoxia, n = 12) and then anesthetized and ventilated to enable phrenic nerve recordings. Baseline phrenic output and blood pressure were similar between groups. Sixty minutes after exposure to acute intermittent hypoxia (AIH), inspiratory phrenic burst amplitude was +66 ± 47 (HBO) and +43 ± 13 % baseline (normoxia). Thus, both groups expressed phrenic long-term facilitation, pLTF (time effect, P = 0.008). The pLTF magnitude had a larger coefficient of variation after HBO (71 %) vs . normoxia (30 %). This resulted from a bimodal data distribution, with 4 of 12 HBO rats showing pLTF > +70 % baseline ( vs. 0 of 12 normoxia). We conclude that acute HBO does not impact baseline phrenic output in this preparation, but further study of HBO and phrenic neuroplasticity is warranted.

Source: Respiratory Physiology & Neurobiology

DOI: 10.1016/j.resp.2025.104399

Authors: Prajwal P. Thakre, Kyle M. Deegan, David D. Fuller

Institutions: University of Florida Health, University of Florida

Language: English

Topic: Neuroscience of respiration and sleep

Subfield: Endocrine and Autonomic Systems

Field: Neuroscience

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: hybrid

Estimated APC paid: $3,450