Work

Isolated Testicular Metastasis From Prostate Cancer: A Rare Presentation 15 Years Posttreatment

Year: 2025

Type: article

Abstract: Testicular metastases from prostate cancer (PCa) are exceedingly rare and are typically accompanied by other metastatic sites. We present the case of an 82-year-old male patient who developed isolated testicular metastasis 15 years after undergoing radiotherapy and androgen deprivation therapy (ADT) for localized PCa. The patient presented with a palpable left testicular mass, which was confirmed to be a metastatic prostate adenocarcinoma by histopathological and immunohistochemical analyses. Orchiectomy was performed for both diagnostic and therapeutic purposes, resulting in a significant decline in serum PSA levels. The patient continued ADT with regular monitoring, and no further metastases were detected. This case highlights the importance of long-term surveillance and advanced diagnostic techniques for detecting the rare metastatic presentations of PCa. Although isolated testicular metastases may have a better prognosis than other metastatic patterns, optimal postorchiectomy management remains uncertain, underscoring the need for further research and a multidisciplinary approach.

Source: Cureus

DOI: 10.7759/cureus.78571

Authors: Tauqir Aslam Waraich, Syed Yousaf Khalid, Asadullah Aslam, Claudio Lizarralde, Syed Jaffry

Institutions: Letterkenny University Hospital, University Hospital Galway, St. James's Hospital, Galway Clinic

Language: English

Topic: Prostate Cancer Treatment and Research

Subfield: Pulmonary and Respiratory Medicine

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: diamond

OpenAlex ID: W4407162356