Work

Contact and communication: ZO ‐2 and the Hippo pathway

Year: 2025

Type: article

Abstract: The PDZ domain-containing protein ZO-2 is defined as a tight junction (TJ) protein, but is also known to have a role in the maintenance of cellular apicobasal polarity and to function as a signalling molecule in several pathways, including the Hippo pathway. In this issue, Liu OX et al. [(2024) FEBS J, https://doi.org/10.1111/febs.17304] report how the multiple protein binding sites of ZO2 protein allow it to act as a scaffold to facilitate its signalling functions.

Source: FEBS Journal

DOI: 10.1111/febs.17417

Author: Miranda Thomas

Institution: International Centre for Genetic Engineering and Biotechnology

Language: English

Topic: Hippo pathway signaling and YAP/TAZ

Subfield: Cell Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

Open Access status: hybrid

Estimated APC paid: $5,000

Funders: Fondazione AIRC per la ricerca sul cancro ETS, Associazione Italiana per la Ricerca sul Cancro