Year: 2025
Type: preprint
Abstract: Three-dimensional (3D) high-resolution imaging is essential in microscopy, yet light scattering poses significant challenges in achieving it. Here, we present an approach to holographic imaging of spatially incoherent objects through scattering media, utilizing a virtual medium that replicates the scattering effects of the actual medium. This medium is constructed by retrieving mutually incoherent fields from the object, and exploiting the spatial correlations between them. By numerically propagating the incoherent fields through the virtual medium, we non-invasively compensate for scattering, achieving accurate 3D reconstructions of hidden objects. Experimental validation with fluorescent and synthetic incoherent objects confirms the effectiveness of this approach, opening new possibilities for advanced 3D high-resolution microscopy in scattering environments.
Source: arXiv (Cornell University)
Language: English
Subfield: Atomic and Molecular Physics, and Optics
Field: Physics and Astronomy
Domain: Physical Sciences
Open Access status: green
Awards: Dynamic adaptive microscopy for label-free multi-parametric imaging in biology and medicine, G4573130097, G4937468798, Scattering Media as a Resource Towards Information Processing and Sensing, Fluorescence-based optical phase conjugation through scattering media, G6200768123, G6604153567, Dynamic adaptive microscopy for label-free multi-parametric imaging in biology and medicine
OpenAlex ID: W4407174598