Work

Author response: HERV activation segregates ME/CFS from fibromyalgia while defining a novel nosologic entity

Year: 2025

Type: peer-review

Abstract: AssessmentThis important study investigates the implications of human endogenous retrovirus (HERV) activity in myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) and fibromyalgia (FM).These findings indicate significant associations that coincide with previous literature, which has suggested roles for differential HERV activity in degenerative, inflammatory, and aging-related pathologies of the central nervous system (CNS), as well as neurotropic infections.These seminal studies can be strengthened with minor improvements to the methodologies of characterizing differential HERV activity, further characterizing downstream mechanisms by which HERV activity impacts disease and by an expansion of the datasets utilized to include additional cohorts.These compelling findings are of immediate importance to clinicians, policymakers, and researchers interested in the underlying etiology of human health and disease.

Source: eLife

DOI: 10.7554/elife.104441.1.sa0

Authors: Karen Giménez-Orenga, Eva Martín-Martínez, Lubov Nathanson, Elisa Oltra

Institutions: Valencia Catholic University Saint Vincent Martyr, National Health Service, Hospital de Manises, Nova Southeastern University

Language: English

Topic: Fibromyalgia and Chronic Fatigue Syndrome Research

Subfield: Psychiatry and Mental health

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $2,500