Year: 2025
Type: article
Abstract: Building on our previously established chiral‐at‐metal approach, in which the overall chirality of the transition metal catalyst is solely determined by a stereogenic metal center, we here present a new addition to the family of C2‐symmetric chiral‐at‐ruthenium catalysts. These are C2‐symmetric chiral ruthenium complexes featuring strongly σ‐donating 1,2,3‐triazol‐5‐ylidene mesoionic carbene (MIC) ligands. The complexes demonstrate excellent catalytic activity and enantioselectivity in a nitrene‐mediated ring‐closing C(sp3)−H amination of an aliphatic azide, leading to the formation of an N‐Boc‐protected chiral pyrrolidine. This study highlights the potential of this new class of chiral mesoionic carbene ruthenium complexes to further enhance or modify the reactivity of ruthenium‐based chiral‐at‐metal catalysts.
Source: Chemistry - A European Journal
Institution: Philipps University of Marburg
Language: English
Subfield: Organic Chemistry
Field: Chemistry
Domain: Physical Sciences
Open Access status: hybrid
Estimated APC paid: $4,640
OpenAlex ID: W4407179848