Work

Sleep-administered ketamine/psychedelics: A streamlined strategy to address two challenges in research on ketamine and psychedelics

Year: 2025

Type: article

Abstract: The dissociative effects of ketamine and psychedelics might be associated with their rapid antidepressant properties, raising questions about whether these effects are necessary for their therapeutic action. Additionally, the distinct dissociative experiences often reported by patients in clinical trials may reveal whether they receive an active treatment or a placebo, potentially introducing bias into the results. In this viewpoint, we propose administering ketamine/psychedelics to patients during sleep, offering a novel approach to address and explore these challenges.

Source: European Psychiatry

DOI: 10.1192/j.eurpsy.2025.14

Authors: Shokouh Arjmand, Mats B. Lindström, Carl M. Sellgren, Gregers Wegener

Institutions: Aarhus University, Karolinska Institutet, Lund University, Stockholm Health Care Services, Aarhus University Hospital

Language: English

Topic: Psychedelics and Drug Studies

Subfield: Clinical Psychology

Field: Psychology

Domain: Social Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $3,300