Work

From a clinically relevant pain target to a possible analgesic treatment strategy

Year: 2025

Type: article

Abstract: Developing new analgesic treatments has been an extraordinary challenge, and unfortunately most attempts in the last three decades have failed. This is particularly true for the treatment of neuropathic pain, a debilitating disease characterized by abnormal chronic pain sensations that can develop after an injury to the somatosensory system. As a result, the therapeutic strategies available for neuropathic pain have not changed in at least 30 years, and consist mainly of gabapentinoids, anticonvulsants, antidepressants and morphine [1,2].

Source: Neurotherapeutics

DOI: 10.1016/j.neurot.2025.e00542

Author: Alban Latremoliere

Institutions: Johns Hopkins University, Johns Hopkins Medicine, Johns Hopkins Hospital

Language: English

Topic: Pain Mechanisms and Treatments

Subfield: Physiology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $3,900