Work

Cytological and histopathological bone marrow findings in dogs with natural Babesia rossi infection

Year: 2024

Type: article

Abstract: -infected dogs and five healthy control dogs. Findings were interpreted together with the circulating haemogram, a Perls' Prussian blue special stain for iron and immunohistochemical markers CD3, CD20, MUM-1, MAC387 and CD204. Infected dogs had an inflammatory leukogram, inappropriately regenerative anaemia, hypercellular bone marrow due to erythroid hyperplasia, dyserythropoietic changes within the metarubricyte population, a myeloid hyperplasia with a left shift, a significant increase in the number of CD204-positive resident macrophages, a left shift within the megakaryocyte population and a significantly increased iron content. Whether iron-restricted erythropoiesis plays a role in the anaemia of canine babesiosis could not be established in this study. Our findings concur with what has been recorded in the bone marrow of humans with falciparum malaria and confirm that dyserythropoiesis is partially responsible for the inappropriate erythroid response in canine babesiosis.

Source: Journal of the South African Veterinary Association

DOI: 10.36303/jsava.626

Authors: MM Bumby, SJ Clift, EH Hooijberg, AL Leisewitz

Institutions: University of Pretoria, Auburn University

Language: English

Topic: Vector-borne infectious diseases

Subfield: Parasitology

Field: Immunology and Microbiology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $65