Year: 2025
Type: article
Study design: Observational Study
Abstract: AIMS: To investigate systemic risk factors contributing to the formation of sialolithiasis. METHODS: A retrospective big-data cohort study was conducted using data from Clalit HMO in Israel. Sialolithiasis patients were identified based on ICD-10 codes and matched with controls. Univariate and multivariable logistic regression analyses were performed to assess the relationship between systemic conditions and sialolithiasis. P-value < 0.05 was considered significant. RESULTS: 5100 sialolithiasis cases were collected. The statistical analysis revealed that hypertension (OR = 1.14, 1.08-1.24, p < 0.001), dyslipidemia (OR = 1.33, 1.27-1.41, p < 0.001), nephrolithiasis (OR = 1.55, 1.42-1.63, p < 0.001) and cholelithiasis (OR = 1.22, 1.16-1.27, p < 0.001) were significantly correlated with sialolithiasis. CONCLUSIONS: Systemic diseases, particularly dyslipidemia, play a role in the development of sialolithiasis. Further research is needed to explore the underlying mechanisms linking these conditions and to develop targeted strategies for the prevention of sialolithiasis. CLINICAL RELEVANCE: This study highlights the potential interplay between systemic conditions and sialolithiasis. Recognizing these associations can inform clinical practice in understanding the pathogenesis of the disease, risk assessment, early diagnosis, and preventive measures.
Source: Clinical Oral Investigations
Institutions: Tel Aviv University, Rabin Medical Center
Language: English
Subfield: Physiology
Field: Medicine
Domain: Health Sciences
Open Access status: hybrid
Estimated APC paid: $4,790
Funder: Tel Aviv University
OpenAlex ID: W4407185180