Work

Transcriptomic profiling of symptomatic and end-stage SOD1-G93A transgenic mice reveals extracellular matrix components as key players in ALS pathogenesis

Year: 2025

Type: article

Abstract: ALS is a neurodegenerative disease marked by the loss of motor neurons. Damaged neurons are not regenerated but attract immune cells, fibroblasts, and astrocytes. Research suggests fibrosis and inflammation contribute to ALS progression. This study profiled spinal cord tissues from SOD1-G93A male mice at different disease stages using RNA sequencing. We identified differentially expressed genes and pathways linked to disease progression. We highlighted notable changes in ECM-related genes: Fmod, S100a4, S100a6 and Col1a1. These findings provide insights into ALS pathology and potential therapeutic targets.

Source: Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease

DOI: 10.1016/j.bbadis.2025.167707

Authors: Simona Rossi, Martina Milani, Ilaria Della Valle, Savina Apolloni

Institutions: Istituto di Farmacologia Traslazionale, National Research Council, University of Rome Tor Vergata

Language: English

Topic: Amyotrophic Lateral Sclerosis Research

Subfield: Neurology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: hybrid

Estimated APC paid: $4,010