PVP‐I Catalyzed Hydroxysulfurization of α ‐(Trifluoromethyl)‐Styrenes with Thiols: Access to Trifluoromethyl Tertiary Alcohol
Year: 2025
Type: article
Abstract: An efficient method for the synthesis of β ‐hydroxy‐ β ‐CF 3 ‐thioether has been developed, utilizing povidone‐iodine (PVP‐I) as a recyclable catalyst and air as the oxidant. The reaction proceeded smoothly at room temperature, yielding the desired β ‐hydroxy‐ β ‐CF 3 ‐thioether in moderate to good yields. This method can be scaled up to gram‐scale without losing any reaction efficiency. The catalyst was also recyclable up to 8 repetitions. The reaction mechanism was investigated and plausible reaction pathway was proposed.
Source: ChemistrySelect
Institution: East China University of Science and Technology
Language: English
Subfield: Organic Chemistry
Field: Chemistry
Domain: Physical Sciences
Open Access status: bronze
OpenAlex ID: W4407223003