Visible-Light-Mediated Aerobic α-Oxygenation of Tetrahydroisoquinolines and Isoindolines Without External Photocatalysts
Year: 2025
Type: article
Abstract: -substituted tetrahydroisoquinolines and isoindolines to the corresponding benzo-fused lactams under clean conditions without using any external photocatalysts has been developed. The reaction was performed in the presence of a catalytic amount of base and oxygen. Mechanistic studies reveal that the reaction is initiated by the substrates themselves as photosensitizers. Additionally, BHT could be used as a buffer-like additive to improve reaction selectivity and product yield in this photo-oxidation process.
Source: Molecules
Authors: Taiqiang Ye, Yuzheng Li, Feng Zhao, Aorou Song, Zhaoxia Zhong, Shenpeng Tan, Feng Li
Institution: Yantai University
Language: English
Subfield: Organic Chemistry
Field: Chemistry
Domain: Physical Sciences
Open Access status: gold
Estimated APC paid: $3,258
Award: G3551526862
OpenAlex ID: W4407223681