Work

BRAF V600E-mutated lung adenocarcinoma with thyroid metastasis as the initial manifestation: a case report

Year: 2025

Type: article

Abstract: Thyroid metastasis of lung adenocarcinoma is exceedingly uncommon. Here we present a case of a 72-year-old Chinese male with hoarseness, dysphagia, pain, and palpable thyroid nodules. Ultrasonography-guided thyroid fine-needle aspiration cytology (FNAC) suggested a high-grade follicular-derived thyroid carcinoma (HGFCTC). Molecular analysis identified a BRAF V600E mutation. Comprehensive histopathological and immunohistochemical examinations, however, revealed that the thyroid cancer originated from the left lung. The patient received a 6-month post-operative dual-target therapy with dalafenib and trametinib. As of the last follow-up, the patient was still alive, demonstrating the effectiveness of targeted therapy.

Source: Frontiers in Oncology

DOI: 10.3389/fonc.2025.1468233

Authors: Yufei Liu, Hanhan Lei, Lingling Cai, Yuyan Tan, Xinyu Song

Institutions: China Three Gorges University, Yichang Central People's Hospital

Language: English

Topic: Metastasis and carcinoma case studies

Subfield: Pulmonary and Respiratory Medicine

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $3,801