Comparative safety and efficacy of new-generation single-layer polytetrafluorethylene- versus polyurethane-covered stents in patients with coronary artery perforation for the RECOVER (REsults after percutaneous interventions with COVERed stents) Investigators
Year: 2025
Type: article
Abstract: New-generation single-layer polytetrafluorethylene (PTFE-) or polyurethane (PU-) covered stent (CS) for the treatment of coronary artery perforation (CAP) during PCI offer high procedural efficacy. To evaluate the comparative long-term safety and efficacy of both devices. This is a multicenter pooled analysis of individual data of patients with CAP undergoing implantation of single-layer PTFE-CS or PU-CS. Procedural endpoint was strategy success defined as successful placement of CS and sealing of perforation without surgical conversion. Clinical endpoints were mortality, myocardial infarction (MI), target vessel revascularization (TVR) and definite or probable stent thrombosis (def/prob ST) at 12 months. Seventy patients with CAP underwent implantation of two hundred eight CS, ninety-two PTFE-CS, and one hundred sixteen PU-CS. More than 1 stent was implanted in 13 patients (17.1%) in PTFE-CS group and 19 patients (20.2%) in PU-CS group, P = 0.80. Strategy success was high (96.1% versus 92.5%., P = 0.62). At 12 months, 71 patients (93.2%) in PTFE-CS group versus 79 patients (81%) in the PU-CS were alive, P = 0.05; TVR occurred in 14 patients (28.4%) in PTFE-CS group and 12 patients (17.9%) in PU-CS group, P= 0.54; MI in 1 patient (1.3%) in PTFE-CS group and 1 patients (1.1%) in PU-CS group, P = 0.86. Rates of def/prob ST were comparable 1.3% in PTFE-CS versus 3.1% in PU-CS P = 0.95. A strategy of implantation of a new-generation single-layer PTFE- or PU-CS for the treatment of coronary artery perforation showed high success rates. Both new-generation CS showed favorable and similar clinical safety, in particular with regard to thrombotic events.
Authors: Felix Voll, Göran Olivecronab, Miroslaw Ferenc, Farrel Hellig, Christian Schlundt, Jochen Wöhrle, Salvatore Cassese, Wolfgang Rottbauer, Adam Witkowski, Erion Xhepa, Wiktor Kuliczkowski, Lisa Strauss, Benedikt Schrage, Michael Joner, Constantin von zur Mühlen, Stephane Cook, Tomislav Miljak, Holger Eggebrecht, Eric Eeckhout, Karl-Ludwig Laugwitz, Jacques Monsegu, Heribert Schunkert, Dirk Westermann, Adnan Kastrati, Nicolas Dumonteil, Ralf Birkemeyer, Sebastian Kufner
Institutions: TUM Klinikum, Deutsches Herzzentrum München, Technical University of Munich, Lund University, Skåne University Hospital, University of Wrocław, Wroclaw Medical University, Netcare Sunninghill Hospital, Friedrich-Alexander-Universität Erlangen-Nürnberg, Universität Ulm, Institute of Cardiology, Universität Hamburg, German Centre for Cardiovascular Research, Universitäts-Herzzentrum Freiburg-Bad Krozingen, HFR Freiburg Kantonsspital, Klinikverbund Südwest, Cardiovascular Center Bethanien, Centre Hospitalier Universitaire Vaudois, Groupe Hospitalier Mutualiste de Grenoble, Clinique Pasteur, Cardiologicum Herzklinik Ulm MVZ GmbH
Language: English
Subfield: Surgery
Field: Medicine
Domain: Health Sciences
Open Access status: hybrid
Estimated APC paid: $4,090
Funder: Technische Universität München
OpenAlex ID: W4407233136