Work

Electrosynthesis of benzimidazole-fused quinazolinones via a cascade addition-desulfurization-cyclization process

Year: 2025

Type: article

Abstract: The electrosynthesis of benzimidazole-fused quinazolinones from N -substituted o -phenylenediamines and isothiocyanates via a cascade addition-desulfurization-cyclization process was introduced. This electrochemical approach utilizes the mild and efficient non-metal oxidizing agent, NaI in sub-stoichiometric amounts as an electrolyte/mediator under open-flask conditions. A variety of benzimidazole-fused quinazolinones were prepared in moderate to excellent yields (30–98 %, 10 examples). Additionally, the optimal conditions were successfully applied to the synthesis of benzoxazoloquinazolinones and benzothiazolquinazolinones (30–72 %, 6 examples). This electrochemical process is scalable, while maintaining reaction efficiency even at the gram scale.

Source: Tetrahedron Green Chem

DOI: 10.1016/j.tgchem.2025.100068

Authors: Khuyen Thu Nguyen, Mongkol Sukwattanasinitt, Sumrit Wacharasindhu

Institution: Chulalongkorn University

Language: English

Topic: Quinazolinone synthesis and applications

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

Open Access status: gold

Estimated APC paid: $1,850

Funders: Chulalongkorn University, National Research Council of Thailand