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A Case Report of Severe Bradycardia Associated With Nirmatrelvir-ritonavir Drug-drug Interactions

Year: 2025

Type: article

Abstract: With the increasing use of nirmatrelvir-ritonavir in older COVID-19 patients, adverse drug reactions due to drug-drug interactions have become more frequent. This report describes a patient who experienced severe bradycardia and hypotension following the concurrent use of heart rate-control medications and nirmatrelvir-ritonavir during an active COVID-19 infection. This suggests that clinicians should be cautious when dealing with nirmatrelvir-ritonavir and try their best to avoid serious adverse reactions.

Source: Cardiology Discovery

DOI: 10.1097/cd9.0000000000000150

Authors: Zhiqing Fu, Yan Guo, Shuai Li, Yang Shi

Institutions: Chinese PLA General Hospital, Chinese People's Liberation Army

Language: English

Topic: COVID-19 Clinical Research Studies

Subfield: Infectious Diseases

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: diamond

OpenAlex ID: W4407235503

FWCI:

Cites: 9

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Related to: 10