Work

Divergent Two-Step Total Synthesis of Sclerotioloid A and B

Year: 2025

Type: article

Abstract: A two-step divergent total synthesis of the structurally unique N-propargylated alkaloids sclerotioloid A and B has been achieved. The synthesis relies on a robust aldol-propargylation domino reaction yielding the key divergent intermediate. Single-crystal X-ray structure studies of the natural product sclerotioloid A show that it exists as a helically chiral racemate in the solid state.

Source: Synlett

DOI: 10.1055/a-2535-1219

Authors: Juha H. Siitonen, Minttu Karta, Rajanish R. Pallerla

Institution: Aalto University

Language: English

Topic: Advanced Synthetic Organic Chemistry

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

Open Access status: hybrid

Funders: Aalto-Yliopisto, Luonnontieteiden ja Tekniikan Tutkimuksen Toimikunta

Award: G8717892072