Year: 2025
Type: article
Abstract: Soft-tissue sarcomas are rare, diverse malignant tumors of mesenchymal origin, requiring diagnosis and treatment by a specialized multidisciplinary team. Initial assessment includes radiology and biopsy, followed by wide surgical resection with clear margins for localized cases. Radiotherapy is recommended for large, deep, high-grade tumors or after incomplete resection, while perioperative chemotherapy may be considered for high-risk cases. In oligometastatic disease, combining local and systemic therapies is an option. Anthracycline-based chemotherapy is the first-line treatment in advanced disease, though other drugs show efficacy in certain subtypes. Given the limited options, enrolling in clinical trials is advised for patients needing further treatment.
Authors: César Serrano, Marta Arregui, Irene Carrasco, Nadia Hindi, Javier Martínez-Trufero, Jerónimo Martínez-García, Áurea Molina, Ana Paisán, Raúl Sánchez, María Ángeles Sala
Institutions: Vall d'Hebron Hospital Universitari, Hospital General Universitario Gregorio Marañón, Hospital Universitario Virgen del Rocío, Hospital Universitario Fundación Jiménez Díaz, Hospital Universitario Miguel Servet, Hospital Universitario Virgen de la Arrixaca, Donostiako Unibertsitate Ospitalea, Hospital Universitario Son Espases, Hospital de Basurto
Language: English
Subfield: Pulmonary and Respiratory Medicine
Field: Medicine
Domain: Health Sciences
Open Access status: hybrid
Estimated APC paid: $4,690
OpenAlex ID: W4407253164