Work

An undescribed jatrophane diterpenoid along with known compounds from Euphorbia sororia with tumour multidrug resistance reversal ability

Year: 2025

Type: article

Abstract: An undescribed jatrophane diterpenoid, euphosorophane N (1), along with thirteen known jatrophane diterpenoids (2-14), were isolated from the fructus of Euphorbia sororia, and their chemical structures were elucidated based on extensive spectroscopic analysis, including HRESIMS, 1D and 2D NMR data. The X-ray crystallographic analysis was used to confirm the absolute configurations of compound 6 for the first time. These jatrophane diterpenoids were evaluated for their multidrug resistance (MDR) reversal ability on the cancer cell line HCT-8/Taxol by MTT assay and compounds 3, 5, and 9 revealed promising MDR reversal ability compared to verapamil (VRP).

Source: Natural Product Research

DOI: 10.1080/14786419.2025.2462113

Authors: Hequn Yang, Dan Tang, Jiangyu Zhao, Haji Akber Aisa

Institutions: Chinese Academy of Sciences, Xinjiang Technical Institute of Physics & Chemistry, Technical Institute of Physics and Chemistry

Language: English

Topic: Bioactive Natural Diterpenoids Research

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: green

OpenAlex ID: W4407253176

FWCI:

Cites: 7

Cited by:

Related to: 10