The effects of Dan Shen Chuanxiong qin injection on serum BNP and cardiac troponin levels in patients with acute coronary syndrome: A Biomechanical Perspective
Year: 2025
Type: article
Study design: Clinical Trial
Abstract: Objective: This study aims to evaluate the clinical efficacy of Dan Shen Chuan xiong qin Injection in combination with conventional interventions for Acute Coronary Syndrome (ACS), emphasizing its biomechanical mechanisms and effects on serum levels of B-type natriuretic peptide (BNP) and cardiac troponin T (cTnT). Methods: This prospective cohort study involved 140 patients suffering from ACS, randomly divided into a control group and a treatment group. The control group received conventional Western pharmacotherapy, while the treatment group was additionally treated with Dan Shen Chuan xiong qin Injection. We measured serum BNP and cardiac troponin levels and analyzed their biomechanical relevance to cardiac function and hemodynamics on the 1st, 2nd, and 5th days post-treatment. Results: After treatment, particularly on the 5th day, the BNP levels in the treatment group receiving Dan Shen Chuan xiong qin Injection were significantly lower than those in the control group (p < 0.05). Both groups exhibited a downward trend in BNP levels on days 1, 2, and 5 (p < 0.001). Regarding troponin levels, the treatment group showed lower troponin levels on all days compared to the control group (p < 0.05), with statistically significant differences noted (p < 0.05). Biomechanical Analysis: The reduction in BNP and troponin levels suggests an improvement in cardiac function and hemodynamics, potentially indicating enhanced myocardial performance and reduced cardiac stress. The biomechanical implications of these biomarkers highlight their role in assessing cardiac workload and injury, reinforcing the cardioprotective effects of Dan Shen Chuanxiong Injection. Conclusion: The treatment group receiving Dan Shen Chuanxiong Injection demonstrated superior outcomes in clinical symptom relief, improvement in cardiac function, and reduction in biomarker levels compared to the control group. These findings indicate that Dan Shen Chuan xiong qin Injection possesses significant cardioprotective effects, reducing the risk of cardiac injury through biomechanical mechanisms. When used alongside conventional therapy, DSCXQ Injection shows potential for improving critical biomarkers related to ACS. This study provides valuable evidence for integrating traditional Chinese medicine with conventional Western approaches in managing ACS, emphasizing the importance of biomechanical analysis in understanding therapeutic effects.
DOI: 10.62617/mcb680
Authors: Xinsheng Zhang, Meryl Grace Lansing
Institution: Universiti of Malaysia Sabah
Language: English
Subfield: Complementary and alternative medicine
Field: Medicine
Domain: Health Sciences
Open Access status: diamond
OpenAlex ID: W4407259450