Year: 2025
Type: article
Abstract: We here report the synthesis of two types of six‐membered cyclic carbonate monomers equipped with various drug molecules through ester linkages. The target compounds can be isolated in good yields and feature diagnostic IR and 13 C NMR spectroscopic fingerprints in line with their proposed connectivities. As a potential application, we investigated their ring‐opening polymerization (ROP), showing that the nature of the cyclic carbonate is crucial towards macromolecular carbonate formation. The functionalized polycarbonates have molecular weights of up to 10 kg/mol, controllable functionality and a variable drug‐to‐carbonate ratio. This work demonstrates the adaptive synthesis of new types of functionalized six‐membered cyclic carbonates with potential as precursors to polycarbonate‐drug type macromolecules.
Source: ChemSusChem
Authors: Wangyu Shi, Thirusangumurugan Senthamarai, Matteo Lanzi, Paolo Orlando, Rodrigo Nogués Martín, Arjan W. Kleij
Language: English
Subfield: Process Chemistry and Technology
Field: Chemical Engineering
Domain: Physical Sciences
Open Access status: hybrid
Estimated APC paid: $4,550
Funders: Chinese American Educational Research and Development Association, European Commission, Institució Catalana de Recerca i Estudis Avançats, Institut Català d'Investigació Química, Ministerio de Ciencia e Innovación, Agència de Gestió d'Ajuts Universitaris i de Recerca, H2020 European Research Council
OpenAlex ID: W4407259734