Aqueous‐Mediated Microwave Synthesis of Novel Tetrahydrospiro [Chromeno‐Isoxazole‐Indolinone] Derivatives via 1,3‐Dipolar Cycloaddition Reaction
Year: 2025
Type: article
Abstract: A regiospecific approach has been developed for the synthesis of 2,2‐disubstituted 2‐phenyl‐2,3a,4,9b‐tetrahydrospiro[chromeno[4,3‐d]isoxazole‐1,3’‐indolin]‐2’‐one derivatives via 1,3‐dipolar cycloddition reaction. This one‐pot, two‐component synthesis involves 2H‐chromene and N‐arylisatin nitrones in aqueous medium, promoting a green synthesis by minimizing the use of hazardous reagents and enhancing the sustainability of synthesis. The cycloadducts, which feature a spiro center, are efficiently obtained under both conventional method and microwave irradiation. The newly developed derivatives were characterized using 1H, 13C NMR, as well as HRMS spectra. Furthermore, the structure of compound 16 a was unambiguously confirmed through single‐crystal X‐ray analysis.
Authors: Suhasini Mohapatra, Sonali Priyadarshini Parida, Sabita Nayak, Kabita Behera, Seetaram Mohapatra
Institution: Ravenshaw University
Language: English
Subfield: Organic Chemistry
Field: Chemistry
Domain: Physical Sciences
Open Access status: bronze
OpenAlex ID: W4407260632