Work

A Material Transfer Agreement between Glioblastoma and Normal Brain Cells

Year: 2025

Type: article

Abstract: Tumor cells communicate with normal cells in various ways, typically leading to the exploitation of resources of the normal cells by tumor cells for their benefit. In this issue, Mangena and colleagues use three-dimensional organoid models to show the transfer of GFP and mRNA from malignant glioblastoma to nonmalignant cells in cerebral organoid models; this transfer is facilitated by extracellular vesicles and possibly tunneling nanotubes, demonstrating how nonmalignant cells in the tumor microenvironment can be exploited by neighboring malignant cells. See related article by Mangena et al., p. 299.

Source: Cancer Discovery

DOI: 10.1158/2159-8290.cd-24-1661

Authors: Sajina Shakya, Christopher G. Hubert, Justin D. Lathia

Institutions: Case Comprehensive Cancer Center, Case Western Reserve University, Cleveland Clinic

Language: English

Topic: Extracellular vesicles in disease

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: green

Funders: National Cancer Institute, National Institute of Neurological Disorders and Stroke