Correlation of Zinc Levels on C-Reactive Protein Among Advanced-Stage Non-Small Cell Lung Cancer Patients
Year: 2025
Type: article
Study design: Observational Study
Abstract: Background: Lung cancer is a leading cause of malignancy and mortality. Zinc and C-reactive proteins are known to affect lung cancer progression. However, inconsistent findings between zinc levels on plasma CRP levels were reported. This study aimed to determine the correlation between serum zinc and CRP levels in patients with advanced-stage non-small cell lung cancer (NSCLC) Methods: A cross-sectional study was conducted in the Regional Hospital of Doris Sylvanus Palangkaraya between January and April 2023. Thirty-five lung cancer patients were included. The blood specimen was analyzed for serum Zinc and CRP. Spearman's correlation test was used to analyze the data. Results: The zinc level was dominantly normal or low (71.4%), with a mean of 65.57 ug/dL. Most subjects have elevated CRP, with higher CRP in the deficiency zinc group (96.64 vs. 68.89 mg/L). However, no significant correlation was found between serum zinc and CRP levels (P=0.160; r=0.173). Conclusion: Serum zinc levels were not proven statistically correlated with inflammatory markers (CRP), particularly in non-small lung cancer patients.
Source: Jurnal Respirologi Indonesia
Authors: Nugroho Eko Prasetyo, Haryati Haryati
Institution: Lambung Mangkurat University
Language: English
Topic: Trace Elements in Health
Subfield: Nutrition and Dietetics
Field: Nursing
Domain: Health Sciences
Open Access status: diamond
OpenAlex ID: W4407263114