Year: 2024
Type: article
Abstract: In recent years, there has been an upsurged in the rapid development of asymmetric synthetic methodologies. While varied catalytic modes and catalyst systems have been established, their utility in complex molecular settings remains to be seen. As a burgeoning powerful tool, natural product synthesis represents an excellent testing ground for such protocols. This review highlights the approaches to synthesizing asymmetrically biological natural products. Also, it looks into some of the recent advances in the catalytic asymmetric total synthesis of physiological active compounds of natural products. The strategies and methods of total synthesis described within this review provide impressive examples due to the unprecedented synthetic efficiency (such as the shortest asymmetric total synthesis organocascade. On the other hand, significant challenges remain (such as the industrial scale application in asymmetric drug synthesis). It can be expected that some new breakthroughs (such as lower catalyst loading, higher catalyst activity, more universal catalyst, and more clearly mechanism) in this field will be forthcoming. Keywords:Assymetric Synthesis, Physiological Active Principles, Natural Products
Authors: Ahmed, Aisha Garba, Efeturi A. Onoabedje, Mercy Amarachukwu Ezeokonkwo
Institutions: University of Nigeria, Federal Polytechnic, Mubi
Language: English
Subfield: Organic Chemistry
Field: Chemistry
Domain: Physical Sciences
Open Access status: bronze
OpenAlex ID: W4407295576