Work

Molecular and functional changes in GABAergic transmission during epileptogenesis in a rat model of post-traumatic epilepsy

Year: 2025

Type: article

Abstract: ) was shifted towards more depolarized values in the perilesional cortex and ipsilateral thalamus. Our data demonstrate a rapid onset and long-lasting duration of GABAergic dysfunction after TBI and support the hypothesis that an early treatment with agents modulating the GABAergic transmission in the thalamo-cortical-thalamic circuitry may suppress early seizures as well as prevent or slow down epileptogenesis after TBI.

Source: Experimental Neurology

DOI: 10.1016/j.expneurol.2025.115183

Authors: Noora Puhakka, Pierangelo Cifelli, Gabriele Ruffolo, Alessandro Gaeta, Cristina Roseti, Angela Di Iacovo, Johanna Tiilikainen, Xavier Ekolle Ndode-Ekane, Anssi Lipponen, Meinrad Drexel, Günther Sperk, Asla Pitkänen, Eleonora Palma

Institutions: University of Eastern Finland, University of L'Aquila, Istituto di Ricovero e Cura a Carattere Scientifico San Raffaele, Sapienza University of Rome, University of Insubria, Innsbruck Medical University

Language: English

Topic: Epilepsy research and treatment

Subfield: Psychiatry and Mental health

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: hybrid

Estimated APC paid: $4,110

Funders: European Commission, Academy of Finland, Ministero della Salute, Ministero dell’Istruzione, dell’Università e della Ricerca, Sapienza Università di Roma, Sigrid Juséliuksen Säätiö, Sixth Framework Programme, Horizon 2020

Awards: G2475339710, G2525452296, G4485845963, Mechanisms of microglia-specific genetic variants associated with Alzheimer's disease, G5925363810, G6757901252, G7889953059

OpenAlex ID: W4407308175

FWCI: 1.23

Cites: 43

Cited by: 2

Related to: 10