Work

Electrosynthesis of 1,4-diene derivatives bearing cyclopentene skeleton

Year: 2025

Type: article

Abstract: 1,n-Dual Π systems including 1,4-diene derivatives have been widely used as the elegant radical receptors to promote cascade radical additions to give the highly functionalized polycyclic scaffolds. However, the tedious and complicated preparation of the former deters broad utilization and compromises the practical value. Herein, a straightforward preparation of 1,4-diene derivatives was developed from the easily accessible alkynes and γ,δ-unsaturated carboxylic acids via electrochemical oxidation cyclization and Hofmann elimination. This transformation features with good to excellent yields, functional group compatibility, and selectivity without any Zaitsev elimination product detected.

Source: iScience

DOI: 10.1016/j.isci.2025.111976

Authors: Yaqi Qiao, Xiaoqing Fan, Chengcheng Yuan, Zheng Fang, Chengkou Liu

Institution: Nanjing Tech University

Language: English

Topic: Radical Photochemical Reactions

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

Open Access status: gold

Estimated APC paid: $3,240

Funders: Government of Jiangsu Province, Natural Science Foundation of Jiangsu Province