Work

m7G gene expression and disease risk model construction in patients with herpes zoster

Year: 2025

Type: article

Abstract: This study investigates the association between mRNA levels of genes involved in 7-methylguanosine (m7G) metabolism and the prognosis of herpes zoster. By analyzing the transcriptional profiles of m7G-related genes in herpes zoster from the GSE242252 dataset, it was found that NSUN2, AGO2, and SNUPN were differentially expressed between herpes zoster and normal controls (p < 0.05). AGO2 and SNUPN were negatively correlated with multiple immune cell infiltrations, while NSUN2 was positively correlated with immature B cell infiltration. A nomogram model based on NSUN2, AGO2, and SNUPN was constructed and showed good predictive ability, validated through clinical impact curve analysis (CICA), calibration curve, and decision curve analysis (DCA). The results suggest that a nomogram based on NSUN2, AGO2, and SNUPN can predict the risk of herpes zoster, and the relationship between these genes and immune infiltration may influence the prognosis of herpes zoster.Trial registration: This study was approved by the Institutional Review Board of the Fujian Medical University Union Hospital (No 2023QH003).

Source: Scientific Reports

DOI: 10.1038/s41598-025-88664-3

Authors: Lingling Lu, Fangze Cai, Yukun Luo

Institutions: Fujian Medical University, Union Hospital

Language: English

Topic: Herpesvirus Infections and Treatments

Subfield: Epidemiology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $2,690