Palladium‐Catalyzed Decarboxylative Coupling of Alkynoic Acids with 2‐Alkynylanilines in Ionic Liquid
Year: 2025
Type: article
Abstract: An efficient and reliable NHC‐palladium‐catalyzed cascade decarboxylative coupling of alkynoic acids with 2‐alkynylanilines for the rapid and straightforward assembly of synthetically valuable 3‐alkynylindole derivatives in eco‐friendly medium is described. Control experiments revealed that NHC−Pd catalysts and base were all essential for this catalytic system. More importantly, this approach features mild reaction conditions, excellent functional group compatibility, and reasonable to excellent yields.
Authors: Yin‐Long Lai, Xun Xiong, Ting Zhao, Jianxiao Li, Rui‐Min Zhong, Wenfang Xiong, Huanfeng Jiang
Language: English
Subfield: Organic Chemistry
Field: Chemistry
Domain: Physical Sciences
Open Access status: bronze
OpenAlex ID: W4407351171