Work

A Rare Case Report: Primary Vulvar Adenocarcinoma of Mammary Gland Type

Year: 2025

Type: article

Abstract: Primary vulvar adenocarcinoma of mammary gland type (AMGT) is exceedingly rare and presents significant diagnostic challenges. We report the case of a 70-year-old female with a nodular vulvar lesion, confirmed as vulvar AMGT through comprehensive histological and immunohistochemical analysis. The tumor cells were positive for SOX10, TRPS1, and E-cadherin, and negative for ER, PR, and HER-2/neu, ruling out metastatic breast carcinoma. This case underscores the importance of specific markers like TRPS1 in accurately diagnosing rare vulvar malignancies and guiding effective treatment strategies. Further studies are needed to better understand the pathogenesis and clinical characteristics of vulvar AMGT.

Source: International Journal of Women s Health

DOI: 10.2147/ijwh.s503901

Authors: Xiaomin Dai, Huan Lei, Ruixia Jie

Institution: Zhejiang Hospital

Language: English

Topic: Urinary and Genital Oncology Studies

Subfield: Surgery

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $2,836