A two-photon lensless endoscope with a double-clad tapered multi-core fiber
Year: 2025
Type: article
Abstract: We present a novel, to the best of our knowledge, multi-core fiber-based lensless micro-endoscope incorporating several key innovations: a Fermat's golden spiral core layout, a low-index polymer cladding, and a longitudinally varying fiber diameter. This fiber design enables efficient focusing of ultrashort pulses and collection of the fluorescence signal with both diffraction-limited resolution and field of view. These advancements address several long-standing challenges in the development of ultra miniaturized non-linear endoscopes. We characterize the device's performance by evaluating the Strehl ratio, field of view, and memory effect. Finally, we demonstrate its application to biological cellular samples by performing two-photon excited fluorescence imaging in an endoscopic configuration.
Source: Optics Letters
DOI: 10.1364/ol.550709
Institutions: Institut Fresnel, Méthodes et Outils pour les Sciences Participatives, Université de Lille, Laboratoire de Physique des Lasers, Atomes et Molécules, Centre National de la Recherche Scientifique, Institut de Recherche sur les Composants logiciels et matériels pour l'Information et la Communication Avancée, Inserm, Aix-Marseille Université, Institut de Neurobiologie de la Méditerranée
Language: English
Subfield: Electrical and Electronic Engineering
Field: Engineering
Domain: Physical Sciences
Open Access status: hybrid
Funders: Université de Lille, İslam Tarih, Sanat ve Kültür Araştırma Merkezi, Agence Nationale de la Recherche, Institut National de la Santé et de la Recherche Médicale, IC Design Education Center, Centre National de la Recherche Scientifique, Région Hauts-de-France, National Institutes of Health, National Eye Institute
Awards: Fast and non-invasive multi-mode fiber imaging, INITIATIVE D'EXCELLENCE AIX MARSEILLE UNIVERSITE, G1742243815, G1796686420, DEEPHIPPO: Ultra-thin lensless endoscope for the visualization of deep hippocampus neuronal functional activity., Nonlinear photonic lanterns for spiking neural networks, G3506921593, Centre d'imagerie de la dynamique des circuits neuronaux, G4586079565, G4866930200, G4882121580, G4950536974, G541215150, G782245399, G7826257910
OpenAlex ID: W4407393243