Year: 2025
Type: article
Abstract: Purpose of Review Non-Specific Pleuritis (NSP) is a common diagnosis following thoracoscopy and encompasses a broad range of aetiologies with heterogeneous outcomes. In this article, we review pathophysiology, associated syndromes, and current best practice in follow-up. Recent Findings NSP typically runs a benign disease course; however, the biomechanical consequences of subsequent tissue re-modelling can be severe. A proportion of patients develop malignancy, notably pleural mesothelioma (PM), and clinicians currently lack the ability to stratify those at risk. Some may be harbouring occult malignancy with false-negative pleural biopsies. Alternatively, NSP may represent a true pre-PM precursor supported by the recent characterisation of mesothelioma-in-situ. Summary Prospective surveillance of NSP patients could unlock the final biological milestone preceding PM evolution. Progress in this area would permit a more personalised patient stratification, whilst offering novel opportunities for translational research. The PREDICT-Meso International Accelerator Network has been established to focus on this goal.
Source: Current Pulmonology Reports
Authors: Mark DJ Neilly, Craig Dick, Kevin G Blyth
Language: English
Subfield: Pulmonary and Respiratory Medicine
Field: Medicine
Domain: Health Sciences
Open Access status: hybrid
Estimated APC paid: $3,990
OpenAlex ID: W4407394499