Work

RNA-binding proteins: it's better to play in a band

Year: 2025

Type: preprint

Abstract: Alternative splicing (AS) is regulated by a myriad of RNA-binding proteins (RBPs) in a coordinated manner. However, most studies characterize RBPs individually. In this issue ofGenes & Development, Peyda and colleagues (doi:10.1101/gad.352105.124) revealed how the LASR complex, consisting of multiple RBPs, regulates AS by recognizing multipart sequences. Their approach may be applicable to studying the combinatorial effects of other RBPs, which is critical for cracking the splicing code.

Source: Genes & Development

DOI: 10.1101/gad.352667.125

Authors: Joshua Jeong, Klemens J. Hertel, Yongsheng Shi

Institution: University of California, Irvine

Language: English

Topic: RNA Research and Splicing

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

Open Access status: hybrid

Funders: National Institutes of Health, National Institute of General Medical Sciences, National Institute of Allergy and Infectious Diseases

Awards: mRNA alternative polyadenylation in B cell development, Regulation and impact of alternative splicing in biology and disease, Mechanisms and regulation of mRNA 3' processing