Piezoelectric‐Enhanced Nanocatalysts Trigger Neutrophil N1 Polarization against Bacterial Biofilm by Disrupting Redox Homeostasis (Adv. Mater. 6/2025)
Year: 2025
Type: article
Abstract: Biofilm Eradication In article number 2409633, Min Ge, Chuang Yang, Han Lin, Jianlin Shi, and co-workers developed a physical and chemical barrier breakthrough strategy for biofilms via redox homeostasis manipulation. The nanosystem can enhance the attack of ROS via exogenous stimulation while providing interference with endogenous H2S synthase to reduce the resistance of reducing species, which together lead to severe structural damage in biofilms. In addition, oxidative stress mediates N1 polarization of neutrophils, leading to immunobactericidal effects.
Source: Advanced Materials
Authors: Min Ge, Wanbo Zhu, Jiawei Mei, Tingting Hu, Chuang Yang, Han Lin, Jianlin Shi
Institutions: University of Hong Kong, Shanghai Jiao Tong University, Shanghai Sixth People's Hospital, University of Science and Technology of China, Tongji University, Chinese Academy of Sciences, Chinese Academy of Medical Sciences & Peking Union Medical College, Shanghai Tenth People's Hospital, Shanghai Institute of Ceramics
Language: English
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: bronze
OpenAlex ID: W4407406583