Year: 2025
Type: article
Abstract: Gating is a fundamental and essential process in cytometry data analysis since it defines cell types of interest. Currently, there is no universally accepted method for representing and sharing gating strategies among software, publications, and repositories. I propose using the Prime Population system combined with a modified version of Gödel Numbers to identify any gating strategy uniquely. The Prime Population System is first used to identify gates on bivariate plots; successively, Gödel Numbers are used to set the sequence of the hierarchical gating strategy. The process results are unique identifiers for any existing and future gating strategy. The unique identifiers hold since according to the fundamental theorem of arithmetic, every natural number other than one either is a prime or is a product of prime numbers, and every nonprime number can be factored into a product of prime in only one way. This method represents a further step towards the arithmetization of cytometry metadata.
Source: Frontiers in Immunology
Author: Antonio Cosma
Institution: Luxembourg Institute of Health
Language: English
Subfield: Information Systems
Field: Computer Science
Domain: Physical Sciences
Open Access status: gold
Estimated APC paid: $3,801
OpenAlex ID: W4407419793