Work

Parenteral Nutrition-Induced Liver Function Complications: Incidence, Risk Factors, and Prognosis

Year: 2025

Type: article

Abstract: Background/Objectives: Parenteral Nutrition-Associated Liver Disease (PNALD) is a significant complication in patients undergoing parenteral nutrition (PN). This study aims to explore the incidence, risk factors, and outcomes associated with PNALD, including abnormal liver function tests, in patients receiving parenteral nutrition, even in short-term PN recipients. Methods: A retrospective analysis of 500 patients receiving PN for at least 3 days at a tertiary medical center was conducted. Liver enzyme levels were monitored for 28 days, and PN duration, comorbidities, and metabolic factors were analyzed to identify independent risk factors of abnormal liver function tests and PNALD. Results: This study reported a 24.4% incidence of abnormal liver function tests and an 8.2% incidence of PNALD. Risk factors for abnormal liver function tests included liver disease (OR 2.064, 95% CI 1.224–3.479), infection (OR 1.654, 95% CI 1.075–2.546), PN duration (OR 1.035, 95% CI 1.014–1.056), and PN calories (OR 1.001, 95% CI 1.000–1.002). Significant PNALD risk factors comprised liver disease (OR 3.623, 95% CI 1.670–7.858), lung disease (OR 3.648, 95% CI 1.615–8.240), recent surgery (OR 3.719, 95% CI 1.645–8.407), PN duration (OR 1.041, 95% CI 1.016–1.068), total cholesterol (OR 1.005, 95% CI 1.000–1.010), and HDL-cholesterol (OR 1.012, 95% CI 1.001–1.023). The majority of PNALD cases (85.3%) showed improvement with PN modification or cessation. Conclusions: This study underscores that abnormal liver function tests and PNALD risks can emerge with short-term PN use. Identifying and addressing patient-specific risk factors is vital for predicting and preventing PNALD onset.

Source: Journal of Clinical Medicine

DOI: 10.3390/jcm14041220

Authors: Jae Woo Park, Sun Ah Maeng, Sang Gyune Kim, Young Seok Kim, Jeong-Ju Yoo

Institutions: Soonchunhyang University, Soonchunhyang University Hospital Bucheon

Language: English

Topic: Clinical Nutrition and Gastroenterology

Subfield: Nutrition and Dietetics

Field: Nursing

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $3,137