Work

Raised Creatine Kinase with Numerous Antipsychotics Responded to Clozapine

Year: 2025

Type: article

Abstract: There is much uncertainty on continuing antipsychotics where a patient has an asymptomatic rise in creatine kinase. This case report describes a patient in his late 20s and early 30s with an established diagnosis of schizophrenia. He experienced multiple asymptomatic rises in creatine kinase (CK) when treated with numerous antipsychotics, which led to them being discontinued. Eventually, successful treatment was undertaken when clozapine was trialled. This led to improved quality of life scores when objectively measured, as well as good tolerance with no physical health sequelae. In conclusion, we recommend that clozapine is considered when other antipsychotic medications lead to elevated CK levels or neuroleptic malignant syndrome.

Source: Psychopharmacology Bulletin

DOI: 10.64719/pb.4524

Authors: Michael Dixon, Richard Nixon, James O’Neill, Nick Venters

Institutions: Seacroft Hospital, Leeds and York Partnership NHS Foundation Trust, South West Yorkshire Partnership NHS Foundation Trust

Language: English

Topic: Schizophrenia research and treatment

Subfield: Psychiatry and Mental health

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

OpenAlex ID: W4407426832

FWCI: 1.264

Cites:

Cited by: 2

Related to: 10