Work

Restoring the supply lines: removing roadblocks to fatty acid uptake enhances T cell-driven cancer fight

Year: 2025

Type: article

Abstract: In a recent study published in Nature , Hwang et al. 1 show that the tumor microenvironment (TME) constrains tumor-infiltrating CD8 + T cell responses by curtailing fatty acid uptake and utilization through endoplasmic reticulum (ER) stress-induced transgelin 2 (TAGLN2) suppression. Overexpression of TAGLN2 in CD8 + T cells bypasses the ER stress response, restoring fatty acid shuttling, bioenergetic fitness, and antitumor efficacy.

Source: Signal Transduction and Targeted Therapy

DOI: 10.1038/s41392-025-02151-9

Authors: Jeremy G. Baldwin, Caio R. F. Silveira, Luca Gattinoni

Institutions: Leibniz Institute for Immunotherapy, University Hospital Regensburg, University of Regensburg

Language: English

Topic: Cancer, Lipids, and Metabolism

Subfield: Cancer Research

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $3,790