Work

“Better Late Than Never”—Late‐Onset Genotype‐Negative Congenital Long QT Syndrome: Case Report and Review

Year: 2025

Type: article

Abstract: Congenital long QT syndrome (LQTS) is a genetic disorder causing prolonged QT intervals and an increased risk of arrhythmias and sudden cardiac death. With 25% of cases lacking known genetic mutations, diagnosis and treatment can be challenging. We present a successfully managed case of late-onset genotype-negative phenotype-positive LQTS presenting as palpitations, complicated by a single event of polymorphic ventricular tachycardia, followed by a review of the literature. This case underscores the gaps in understanding congenital long QT syndrome, especially in genotype-negative cases, and highlights the need for ongoing research for risk assessment and effective management to prevent fatal cardiac events.

Source: Clinical Case Reports

DOI: 10.1002/ccr3.70201

Authors: Clement Tan, Vaikunthan Thanabalasingam, Chaminda Sella Kapu, Zhihua Zhang

Institutions: Mackay Base Hospital, Mackay Hospital and Health Service, Jaffna Teaching Hospital, James Cook University

Language: English

Topic: Cardiac electrophysiology and arrhythmias

Subfield: Cardiology and Cardiovascular Medicine

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $1,820