Work

Modern tools for the functionalization of C(sp3) centers by catalysis

Year: 2025

Type: article

Abstract: In the quest for molecular complexity, the direct and selective functionalization of C(sp 3 ) centers is of paramount importance. As sulfur- and/or fluorine-containing molecules are particularly important, the development of methods to (regio)selectively introduce moieties containing these atoms on a C(sp 3 ) center by direct C–H bond functionalization or decarboxylative reaction has garnered our interest in the last few years. Given the challenges that the direct functionalization of C(sp 3 ) centers represents, this account summarizes our recent contributions thanks to strategies based on transition metal catalysis and photochemistry.

Source: Comptes Rendus Chimie

DOI: 10.5802/crchim.338

Authors: Floris Buttard, Tatiana Besset

Institutions: Centre National de la Recherche Scientifique, Laboratoire COBRA, Université de Rouen Normandie, Institut National des Sciences Appliquées Rouen Normandie

Language: English

Topic: Catalytic C–H Functionalization Methods

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

Open Access status: diamond

Funder: Agence Nationale de la Recherche

Awards: XLChem, Synthesizing our future, Design of Modern Approaches for the (Asymmetric) Synthesis of Original Fluorinated Molecules, Accessing Isotopically Labeled SCF3 and CF3-containing Derivatives using Sulfur and Carbon Strategies, Synthèse Organique : des molécules au vivant