Work

MCF7 breast cancer anabolic capacity reduced with CRISPR/Cas9-mediated stable overexpression of DEPTOR

Year: 2025

Type: article

Abstract: We identify DEPTOR as a predictor of mortality in breast cancer and show that precision gene editing to restore DEPTOR expression in breast cancer slows cell growth by inhibiting mTOR activity.

Source: American Journal of Physiology-Cell Physiology

DOI: 10.1152/ajpcell.00682.2023

Authors: J. William Deaver, Patrick J. Ryan, Colleen L. O’Reilly, Selina Uranga, Sara Mata López, Melinda Sheffield-Moore, Peter P. Nghiem, Steven E. Riechman, James D. Fluckey

Institution: Texas A&M University

Language: English

Topic: PI3K/AKT/mTOR signaling in cancer

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: hybrid

OpenAlex ID: W4407518363

FWCI: 0.252

Cites: 29

Cited by: 1

Related to: 10