Work

The mechanism of action of clozapine

Year: 2025

Type: article

Abstract: Previous hypotheses for the superiority of clozapine over other antipsychotics have failed to stand the test of time. Here we describe how the unique pharmacology of clozapine in the peripheral nervous system held clues for solving the puzzle of clozapine in the central nervous system. Clozapine appears to have been the prototype for a new class of antipsychotics, now entering clinical psychiatry, which activates muscarinic acetylcholine receptors.

Source: Journal of Psychopharmacology

DOI: 10.1177/02698811251319458

Authors: Paul D Morrison, Sameer Jauhar, Allan H Young

Institutions: King's College London, NHS Highland, South London and Maudsley NHS Foundation Trust

Language: English

Topic: Schizophrenia research and treatment

Subfield: Psychiatry and Mental health

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: hybrid

Estimated APC paid: $4,400