Work

Mechanotransduction in the Perivascular Adipose Tissue

Year: 2025

Type: article

Abstract: Perivascular adipose tissue is of compelling interest when considering tissue mechanotransduction. Because of its location around a vessel, perivascular adipose tissue experiences from high (artery) to low (vein) pressures, pressures that are cyclical in nature. With blood pressure change, such as the elevation of pressure in hypertension, the question has been raised as to whether perivascular adipose tissue senses such changes, evidenced by a response that can be genetic, structural, or mechanical in nature. Here, we briefly review the following knowledge and data that support the ability of perivascular adipose tissue to both (mechano)sense and (mechano)respond.

Source: Arteriosclerosis Thrombosis and Vascular Biology

DOI: 10.1161/atvbaha.124.321688

Authors: Stephanie W. Watts, Teresa Krieger-Burke, Rance Nault, G. Andres Contreras

Institution: Michigan State University

Language: English

Topic: Cardiovascular Disease and Adiposity

Subfield: Cardiology and Cardiovascular Medicine

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: bronze

Funder: National Heart, Lung, and Blood Institute