Work

Exosome technology: A novel and effective drug delivery system in the field of cancer therapy

Year: 2025

Type: article

Abstract: In this article, we revisit an article, which specifically focuses on the utilization of exosomes derived from human bone marrow mesenchymal stem cells (MSCs) for targeted delivery of gemcitabine in pancreatic cancer treatment. The experimental results demonstrated that the exosome-based drug delivery system derived from MSCs significantly augmented apoptosis in pancreatic cancer cells. The biocompatibility, targeting specificity, and low immunogenicity of exosomes render them as optimal carriers for drug delivery, enabling precise administration of therapeutics to diseased tissues while mitigating adverse effects, thereby achieving targeted treatment of cancer cells and significantly enhancing anti-tumor efficacy. However, the clinical application of exosome drug delivery platforms in oncology still presents challenges, necessitating further optimization to ensure their stability and efficacy. This study focuses on elucidating the advantages of exosomes as a drug delivery platform, exploring the utilization of MSC-derived exosomes in oncology therapy, and discussing their potential and future directions in cancer treatment.

Source: World Journal of Gastrointestinal Oncology

DOI: 10.4251/wjgo.v17.i3.101857

Authors: Jia-Xin Geng, Yao-Fan Lu, Jing-Nan Zhou, Biao Huang, Yuan Qin

Institutions: Zhejiang Sci-Tech University, Zhejiang University of Science and Technology, Zhejiang Cancer Hospital

Language: English

Topic: Extracellular vesicles in disease

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: diamond

Funders: Thailand Research Fund, Office of National Higher Education Science Research and Innovation Policy Council