Work

UXT oligomerization is essential for its role as an autophagy adaptor

Year: 2025

Type: article

Abstract: . Collectively, our research emphasizes the crucial importance of UXT oligomerization in its role as an autophagy adaptor and explains why the structurally and functionally similar prefoldin, which lacks such high-order oligomerization capacity, is employed for the refolding of individual misfolded proteins, but not autophagy.

Source: iScience

DOI: 10.1016/j.isci.2025.112013

Authors: Min Ji Yoon, Jugeon Park, MinHyeong Lee, Jiyeon Ohk, Tae Su Choi, Eun Jung Choi, Hosung Jung, Chungho Kim

Institutions: Korea University, Yonsei University, Yonsei University Health System, Potomac Affinity Proteins (United States)

Language: English

Topic: Autophagy in Disease and Therapy

Subfield: Epidemiology

Field: Medicine

Domain: Health Sciences

Open Access status: gold

Estimated APC paid: $3,240

Funders: Korea University, National Research Foundation of Korea

Awards: G6471602708, G7359405542, G7436158720

OpenAlex ID: W4407553506

FWCI:

Cites: 37

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Related to: 10