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Modified Early Warning Score (MEWS) combined with biomarkers in predicting 7-day mortality in traumatic brain injury patients in the emergency department: a retrospective cohort study

Year: 2025

Type: article

Abstract: Background: Traumatic brain injury (TBI) is a leading cause of injury-related disability and death globally, which negatively affects individuals, families, and society. Predicting the risk for mortality among TBI patients is crucial in guiding further timely and effective treatment plans. Both the standard risk assessment tools and blood-based biomarkers are helpful in predicting outcomes among TBI patients. However, no studies have compared the predicting performance of the individual and combined indicators from the two major types. Aim: This study aimed to compare the Modified Early Warning Score (MEWS), Red blood cell distribution width (RDW), and creatine in predicting 7-day mortality among TBI patients. Methods: A retrospective study was conducted in the emergency department of the First People's Hospital of Changde, China, from January 1, 2023, to June 30, 2023. Data of 1,701 patients with TBI were obtained from the hospital's electronic medical records. A logistic regression model was used to determine independent factors influencing 7-day mortality. The area under the curve (AUC) of the receiver operating characteristic curve (ROC) was calculated to compare the individual and combined effects of MEWS, RDW, and creatine in predicting 7-day mortality based on bootstrap resampling (500 times). Results: , temperature, RDW, and creatine were significantly associated with 7-day mortality. MEWS (AUC: 0.843) performed better than RDW (AUC: 0.785) and creatine (AUC: 0.797) in predicting 7-day mortality. MEWS+RDW (AUC: 0.898) performed better than MEWS+creatine (AUC: 0.875) and RDW+ creatine (AUC: 0.822) in predicting 7-day mortality. The combination of all three indicators, MEWS+RDW+creatine, showed the best predicting performance (AUC: 0.906). Conclusion: MEWS performed best in predicting the 7-day mortality of TBI patients, and its predicting performance was improved when combined with blood-based biomarkers such as RDW and creatine. Our findings provide preliminary evidence supporting the combination of MEWS with blood-based biomarkers as a new method for predicting 7-day mortality in patients with TBI.

Source: PeerJ

DOI: 10.7717/peerj.18936

Authors: Shouzhen Zhu, Yongqiang Yang, Boling Long, Li Tong, Jinhua Shen, Xueqing Zhang

Institutions: Central South University, The First People's Hospital of Changde

Language: English

Topic: Traumatic Brain Injury and Neurovascular Disturbances

Subfield: Neurology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $1,395