Work

The Role of IL-17 in the Pathogenesis of Acute Rheumatic Fever

Year: 2025

Type: article

Abstract: Objective: In this study, our aim is to determine the interleukin 17 (IL-17) and interleukin 22 (IL-22) levels in acute rheumatic fever (ARF) and rheumatic heart disease (RHD) patients and their relationship with rheumatic fever pathogenesis.Methods: Newly diagnosed 7 ARF patients and 14 RHD patients who are followed by Akdeniz University Faculty of Medicine, Pediatric Cardiology Department and 15 age and sex-appropriate healthy children as the control group were enrolled in this study.Interleukin 17 and interleukin 22 levels were determined with an enzyme-linked immunosorbent assay.Results: IL-17 levels were undetectable, while the IL-22 level was increased in 1 patient in the ARF group.Eleven of 14 RHD patients had IL-17 under detectable levels, while 3 had detectable levels.None of the patients had detectable IL-22 levels.In the control group, none had detectable IL-17 or IL-22 levels.Conclusion: Our results showed that IL-17 and IL-22 do not have an important role in ARF pathogenesis.

Source: Archives of Basic and Clinical Research

DOI: 10.5152/abcr.2025.23221

Authors: Bahtınur Yeter, Dilara Fatma Kocacık Uygun, Nilgün Sallakçı, Gayaz Akçurin

Institutions: Erzincan Binali Yıldırım University, Akdeniz University

Language: English

Topic: Streptococcal Infections and Treatments

Subfield: Public Health, Environmental and Occupational Health

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: diamond

Funder: Akdeniz Üniversitesi