Effect of Salvia przewalskii root extract on ethanol voluntary intake and mRNA expression of GABAA receptor subunits in the brain of alcohol-preferring rats
Year: 2024
Type: article
Abstract: Introduction: Literature data and our research have shown that extracts from the underground plant parts of Salvia przewalskii (SP) reduce alcohol intake in animal models. Objective: The study aimed to assess the effect of SP on mRNA expression of GABAA receptor (GABAAR) subunits (alpha 1–4, delta, gamma 2L, gamma 2S) genes in the brain of ethanol-drinking rats. Methods: The investigations were performed on Warsaw high-alcohol-preferring (WHP) and low-alcohol-preferring (WLP) rats treated with the hydroalcoholic (1:1) extract from SP (150 mg/kg, p.o.) for 28 consecutive days. The mRNA expression was measured by RT-PCR analysis in the cortex, striatum, and hippocampus. Results: SP lowered the alcohol intake in WHP animals. The extract down-regulated alpha and gamma subunit expression in WHP rats mainly in the hippocampus, but simultaneously, the delta subunit upregulation was observed. Conclusions: SP’s effect on drinking behavior can be coupled with the modulation of GABAAR subtype expression in the brain of rats.
Source: Herba Polonica
Authors: Michał Szulc, Radosław Kujawski, Alina Szydło, Rami Taqtaq, Marcin Ożarowski, Anna Bogacz, Monika Karasiewicz, Joanna Bartkowiak-Wieczorek, Wanda Dyr, Edyta Wyszogrodzka, Waldemar Buchwald, Artur Adamczak, Agnieszka Gryszczyńska, Ewa Kamińska, Kamila Czora-Poczwardowska, Przemysław Ł. Mikołajczak
Language: English
Subfield: Complementary and alternative medicine
Field: Medicine
Domain: Health Sciences
Open Access status: diamond
OpenAlex ID: W4407567402