Extraction of Marine Polyketides from Different Seaweeds and Analyzing its Antibacterial and Anti-Cancer Activity
Year: 2024
Type: article
Abstract: Aim: Three different seaweeds were collected in the present study and aimed to investigate its antibacterial activity against human bacterial pathogens and anticancer activity against human breast cancer cell lines (MCF-7) respectively.Methods: Three seaweeds were collected and its bioactive compounds were extracted using soxhlet method to determine the minimal inhibitory concentration (MIC) and antibacterial activity against different pathogenic bacteria.Anti-cancer activity of the extracts in breast cancer cell lines (MCF-7) cells using MTT assay method was investigated.Findings: MIC of all three seaweed extracts was found to be 300µg/ml with the inhibitory zones ranging from 8.6 ± 0.75mm to 16.3 ± 1.05mm against the respective bacteria Escherichia coli and Staphylococcus aureus.Antibacterial activity of three different seaweed extracts showed significant inhibitory zones ranging from 13.3 ± 1.05mm to 16.9 ± 0.57mm against the respective bacteria B1 -Escherichia coli, B2 -Staphylococcus aureus, B3 -Staphylococcus epidermidis, B4 -Klebsiella pneumoniae, B5 -Enterobacter sp.Anticancer activity test results revealed IC50 value of about 43.5µg/ml for the brown seaweed extracts after testing in MCF-7 cell lines.Increase in concentration of samples increased the cell cytotoxicity and proliferation of cancer cells were inhibited in a dose dependent manner.Conclusion: Thus, the obtained results would contribute more and induce interest for the development of different medically significant seaweed farming and biotechnological use with growing interest.
Author: Dr. Venkata Nagendra Prasad. B
Language: English
Subfield: Aquatic Science
Domain: Life Sciences
Open Access status: diamond
OpenAlex ID: W4407577781